1494 Ludovico Sforza of Milan invites the King of France, Charles VIII, to invade Naples
1495 The Holy League of Venice in formed to check French advance
- 1498 Pope Alexander VI invites Louis XII to invade Milan
- 1500 Treaty of Granada - Louis and Ferdinand partition Naples. Disputes lead to Battles of Cergnola and Garigliano (1503): Spanish victories
- 1503 Julius II becomes Pope and later forms League of Cambrai against Vanice (1508)
- 1509 Battle of Agnadello: League of Cambrai defeats Venice
- 1511 Julius forms Second Holy League against France
- 1512 Battle of Ravenna - France defeats forces of Holy League
- 1513 Battle of Novara - Holy League defeats France
- 1515 Battle of Marignano - Francis I crushes the Holy League
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